Some of my top methods for fishing a Senko include:

Skipping under docks:  Nothing beats a senko under a dock.  See my other post for more details on skipping them under a dock.

Pre-Spawn & Spawn:  Find a shallow cover springtime, when bass are spawning, and move the boat very slow and methodically so as not to spook the fish.  Cast a Senko out and dead stick it as long as possible.  Watch the line for any sign of a fish biting at it.  If the water is clear enough and you can see fish, cast in the direction of the bass at least 5 feet in front.  Wait for the bass to swim at it.  If you wait long enough, the bass will come back.

Summer:  Find a deep weedline in 8 to 12 ft.  The best weedlines are ones that come to a point, are near a hump, and or have rocks in them.  Position the boat at the edge of the weedline and cast the Senko along the weedline.  If you have a good depth finder, this can help tell exactly where the weedline ends.  Dead stick the senko up to a minute and the cast back out.  This method can pull some large bass in behind others fishing the same spot.

Fall:  In the fall, find the greenest weeds possible and work a senko around the inside edges.  Once again, dead sticking is one of the top methods.

General:  During any season, skipping a Senko under a dock is a great presentation.  When picking a color, I like to match the color to the watercolor and to the predominate baitfish in the lake.  In Darker water, I prefer black.  Clearwater, watermelon or pumpkinseed work well.  In general, the top method for working a senko is deadsticking it.  Where you cast it out and let it sit for up to 1 minute with out moving it.