Some of my top methods for fishing a Senko include:

Skipping under docks:  Nothing beats a senko under a dock.  See my other post for more details on skipping them under a dock.

Pre-Spawn & Spawn:  Find a shallow cover springtime, when bass are spawning, and move the boat very slow and methodically so as not to spook the fish.  Cast a Senko out and dead stick it as long as possible.  Watch the line for any sign of a fish biting at it.  If the water is clear enough and you can see fish, cast in the direction of the bass at least 5 feet in front.  Wait for the bass to swim at it.  If you wait long enough, the bass will come back.

Summer:  Find a deep weedline in 8 to 12 ft.  The best weedlines are ones that come to a point, are near a hump, and or have rocks in them.  Position the boat at the edge of the weedline and cast the Senko along the weedline.  If you have a good depth finder, this can help tell exactly where the weedline ends.  Dead stick the senko up to a minute and the cast back out.  This method can pull some large bass in behind others fishing the same spot.

Fall:  In the fall, find the greenest weeds possible and work a senko around the inside edges.  Once again, dead sticking is one of the top methods.

General:  During any season, skipping a Senko under a dock is a great presentation.  When picking a color, I like to match the color to the watercolor and to the predominate baitfish in the lake.  In Darker water, I prefer black.  Clearwater, watermelon or pumpkinseed work well.  In general, the top method for working a senko is deadsticking it.  Where you cast it out and let it sit for up to 1 minute with out moving it.

Another method to consider in pre-spawn is Carolina Rig.  Tie on a Carolina rig and pick a cove that has a nice drop off, saddle, or deeper flat.  Start by working from shallow to deep.  Tie on a watermelon or pumpkinseed Zoom Centipede with 2/0 hook.  Slowly drag this bait back to the boat.  Ensure you are using a rod that has much sensitivity, as you want to be able to feel every rock, twig, or fish biting.  The water will be cold, so move the bait very slow.  Cover every once of train methodically.  If working from shallow to deep doesn’t work, move your boat into the shallow area and cast to deep.  You can catch many fish you are floating over with this technique.